Trends in Cardiovascular Medicine
Volume 15, Issue 1 , Pages 9-17, January 2005

Signaling to Translational Control Pathways: Diversity in Gene Regulation in Inflammatory and Vascular Cells

  • Stephan W. Lindemann
    • ,
  • Andrew S. Weyrich
    • ,
  • Guy A. Zimmerman

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Guy A. Zimmerman, MD, Director, Program in Human Molecular Biology and Genetics, 15 North 2030 East, Building 533, Room 4220, Salt Lake City, UT 84112, USA. Tel.: (+1) 801-585-0727; fax: (+1) 801-585-0701

Andrew S. Weyrich and Guy A. Zimmerman are at the Department of Internal Medicine and the Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah, USA. Stephan W. Lindemann is at the I1 Medizinische Klinik der Johannes-Gutenberg Universitäet, Mainz, Germany

The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets.

 

PII: S1050-1738(04)00175-6

doi:10.1016/j.tcm.2004.10.004

Trends in Cardiovascular Medicine
Volume 15, Issue 1 , Pages 9-17, January 2005

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