Trends in Cardiovascular Medicine
Volume 15, Issue 1 , Pages 9-17 , January 2005

Signaling to Translational Control Pathways: Diversity in Gene Regulation in Inflammatory and Vascular Cells

  • Stephan W. Lindemann
    • ,
  • Andrew S. Weyrich
    • ,
  • Guy A. Zimmerman

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Guy A. Zimmerman, MD, Director, Program in Human Molecular Biology and Genetics, 15 North 2030 East, Building 533, Room 4220, Salt Lake City, UT 84112, USA. Tel.: (+1) 801-585-0727; fax: (+1) 801-585-0701

References 

  1. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–297
  2. Brewer G. Misregulated posttranscriptional checkpoints: inflammation and tumorigenesis. J Exp Med. 2001;193:F1–F4
  3. Buffon A, Biasucci LM, Liuzzo G, et al. Widespread coronary inflammation in unstable angina. New Engl J Med. 2002;347:5–12
  4. Calkhoven CF, Müller C, Leutz A. Translational control of gene expression and disease. Trends Mol Med. 2002;8:577–583
  5. Ch'ng JL, Shoemaker DL, Schimmel P, et al. Reversal of creatine kinase translational repression by 3′ untranslated sequences. Science. 1990;248:1003–1006
  6. Freedman JE, Loscalzo J. Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation. 2002;105:2130–2132
  7. Galt SW, Lindemann S, Medd D, et al. Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets. Circ Res. 2001;89:509–516
  8. Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001;15:807–826
  9. Glass CK, Witztum JL. Atherosclerosis: the road ahead. Cell. 2001;104:503–516
  10. Huang YS, Richter JD. Regulation of local mRNA translation. Curr Opin Cell Biol. 2004;16:308–313
  11. Jones SA, Rose-John S. The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochimica Biophysica Acta. 2002;1592:251–263
  12. Kaplanski G, Marin V, Montero-Julian F, et al. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol. 2003;24:25–29
  13. Kaspar RL, Gehrke L. Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles. J Immunol. 1994;153:277–286
  14. Klouche M, Bhakdi S, Hemmes M, et al. Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J Immunol. 1999;163:4583–4589
  15. Kozak M. An analysis of vertebrate mRNA sequences: intimations of translational control. J Cell Biol. 1991;115:887–903
  16. Kraiss LW, Weyrich AS, Alto NM, et al. Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells. Am J Physiol. 2000;278:H1537–H1544
  17. Lindemann S, Tolley ND, Dixon DA, et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1 beta synthesis. J Cell Biol. 2001;154:485–490
  18. Lindemann SW, Yost CC, Denis MM, et al. Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci USA. 2004;101:7076–7081
  19. Macdonald P. Diversity in translational regulation. Curr Opin Cell Biol. 2001;13:326–331
  20. Maeshima Y, Sudhakar A, Lively JC, et al. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science. 2002;295:140–143
  21. Mahoney TS, Weyrich AS, Dixon DA, et al. Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes. Proc Natl Acad Sci USA 98. 2001;98:10,284–10,289
  22. Marks AR. Sirolimus for the prevention of in-stent restenosis in a coronary artery. N Engl J Med. 2003;349:1307–1309
  23. Matthews MB, Sonenberg N, Hershey JWB. Origins and principles of translational control. In:  Sonenberg N,  Hershey JWB editor. Translational Control of Gene Expression. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2000;p. 1–31
  24. Mazumder B, Fox PL. Delayed translational silencing of ceruloplasmin transcript in gamma interferon-activated U937 monocytic cells: role of the 3′ untranslated region. Mol Cell Biol. 1999;19:6898–6905
  25. Mazumder B, Muhopadhyay CK, Prok A, et al. Induction of ceruloplasmin synthesis by IFN-γ in human monocytic cells. J Immunol. 1997;159:1938–1944
  26. Mazumder B, Sampath P, Vasudevan S, et al. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. Cell. 2003;115:187–198
  27. Mazumder B, Vasudevan S, Fox PL. Translational control by the 3′-UTR: the ends specify the means. Trends Biochem Sci. 2003;28:91–98
  28. McIntyre TM, Prescott SM, Weyrich AS, et al. Cell–cell interactions: leukocyte–endothelial interactions. Curr Opin Hematol. 2003;10:150–158
  29. McNamara P, Seo S, Rudic RD, et al. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell. 2001;105:877–889
  30. Pradet-Balade B, Boulme F, Beug H, et al. Translation control: bridging the gap between genomic and proteomics?. Trends Biochem Sci. 2001;26:225–229
  31. Raught B, Gingras AC, Sonenberg N. The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA. 2001;98:7037–7044
  32. Sampath P, Mazumder B, Vasudevan S, Fox PL. Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3′ untranslated region. Mol Cell Biol. 2003;23:1509–1519
  33. Schalm SS, Fingar DC, Sabatini DM, et al. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol. 2003;13:797–806
  34. Thurberg BL, Collins T. The nuclear factor-kappa B/inhibitor of kappa B autoregulatory system and atherosclerosis. Curr Opin Lipidol. 1998;9:387–396
  35. Welt FGP, Rogers C. Inflammation and restenosis in the stent era. Arterioscler Thromb Vasc Biol. 2002;22:1769–1776
  36. Weyrich AS, McIntyre TM, McEver RP, et al. Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation. J Clin Invest. 1995;95:2387–2394
  37. Weyrich AS, Elstad MR, McEver RP, et al. Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest. 1996;97:1525–1534
  38. Weyrich AS, Dixon DA, Pabla R, et al. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci USA. 1998;95:5556–5561
  39. Weyrich AS, Lindemann S, Tolley ND, et al. The evolving role of platelets in inflammation. J Thromb Haemost. 2003;1:1897–1905
  40. Yost CC, Denis MM, Lindemann S, et al. Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-α. J Exp Med. 2004;200:671–680

PII: S1050-1738(04)00175-6

doi: 10.1016/j.tcm.2004.10.004

Trends in Cardiovascular Medicine
Volume 15, Issue 1 , Pages 9-17 , January 2005

Article Tools

* Image Usage & Resolution