Trends in Cardiovascular Medicine
Volume 15, Issue 2 , Pages 64-68 , February 2005

Adventitial Progenitor Cells Contribute to Arteriosclerosis

  • Evelyn Torsney
    • ,
  • Yanhua Hu
    • ,
  • Qingbo Xu

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Qingbo Xu, MD, PhD, Department of Cardiac and Vascular Sciences, St George's Hospital, Medical School, Cranmer Terrace, London SW17 0RE, UK. Tel.: (+44) 20-8725-2817; fax: (+44) 20-8725-2812

References 

  1. Barger AC, Beeuwkes R, Lainey LL, et al. Hypothesis: Vasa vasorum and neovascularization of human coronary arteries, a possible role in the pathophysiology of atherosclerosis. N Engl J Med. 1984;310:175–177
  2. Barker SG, Tilling LC, Miller GC, et al. The adventitia and atherogenesis: removal initiates intimal proliferation in the rabbit which regresses on generation of a “neoadventitia”. Atherosclerosis. 1994;105:131–144
  3. Campbell JH, Campbell GR. The role of smooth muscle cells in atherosclerosis. Curr Opin Lipidol. 1994;5:323–330
  4. Caplice NM, Bunch TJ, Stalboerger PG, et al. Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation. Proc Natl Acad Sci U S A. 2003;100:4754–4759
  5. Chignier E, Eloy R. Adventitial resection of small artery provokes endothelial loss and intimal hyperplasia. Surg Gynecol Obstet. 1986;163:327–334
  6. Faggin E, Puato M, Zardo L, et al. Smooth muscle-specific SM22 protein is expressed in the adventitial cells of balloon-injured rabbit carotid artery. Arterioscler Thromb Vasc Biol. 1999;19:1393–1404
  7. Gutterman DD. Adventitia-dependent influences on vascular function. Am J Physiol. 1999;277:H1265–H1272
  8. Han CI, Campbell GR, Campbell JH. Circulating bone marrow cells can contribute to neointimal formation. J Vasc Res. 2001;38:113–119
  9. Hillebrands JL, Klatter FA, Rozing J. Origin of vascular smooth muscle cells and the role of circulating stem cells in transplant arteriosclerosis. Arterioscler Thromb Vasc Biol. 2003;23:380–387
  10. Hillebrands JL, Klatter FA, Van den Hurk BM, et al. Origin of neointimal endothelium and alpha-actin-positive smooth muscle cells in transplant arteriosclerosis. J Clin Invest. 2001;107:1411–1422
  11. Hu Y, Davison F, Ludewig B, et al. Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells. Circulation. 2002;106:1834–1839
  12. Hu Y, Mayr M, Metzler B, et al. Both donor and recipient origins of smooth muscle cells in vein graft atherosclerotic lesions. Circ Res. 2002;91:e13–e20
  13. Hu Y, Davison F, Zhang Z, et al. Endothelial replacement and angiogenesis in arteriosclerotic lesions of allografts are contributed by circulating progenitor cells. Circulation. 2003;108:3122–3127
  14. Hu Y, Zhang Z, Torsney E, et al. Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice. J Clin Invest. 2004;113:1258–1265
  15. Ip JH, Fuster V, Badimon L, et al. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. J Am Coll Cardiol. 1990;15:1667–1687
  16. Kong D, Melo LG, Mangi AA, et al. Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. Circulation. 2004;109:1769–1775
  17. Le Ricousse-Roussanne S, Barateau V, Contreres JO, et al. Ex vivo differentiated endothelial and smooth muscle cells from human cord blood progenitors home to the angiogenic tumor vasculature. Cardiovasc Res. 2004;62:176–184
  18. Li G, Chen SJ, Oparil S, et al. Direct in vivo evidence demonstrating neointimal migration of adventitial fibroblasts after balloon injury of rat carotid arteries. Circulation. 2000;101:1362–1365
  19. Li J, Han X, Jiang J, et al. Vascular smooth muscle cells of recipient origin mediate intimal expansion after aortic allotransplantation in mice. Am J Pathol. 2001;158:1943–1947
  20. Mayr M, Li C, Zou Y, et al. Biomechanical stress-induced apoptosis in vein grafts involves p38 mitogen-activated protein kinases. FASEB J. 2000;14:261–270
  21. Owens GK. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev. 1995;75:487–517
  22. Religa P, Bojakowski K, Maksymowicz M, et al. Smooth-muscle progenitor cells of bone marrow origin contribute to the development of neointimal thickenings in rat aortic allografts and injured rat carotid arteries. Transplantation. 2002;74:1310–1315
  23. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801–809
  24. Saiura A, Sata M, Hirata Y, et al. Circulating smooth muscle progenitor cells contribute to atherosclerosis. Nat Med. 2001;7:382–383
  25. Sakihama H, Masunaga T, Yamashita K, et al. Stromal cell-derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis. Circulation. 2004;110:2924–2930
  26. Sartore S, Chiavegato A, Faggin E, et al. Contribution of adventitial fibroblasts to neointima formation and vascular remodeling: from innocent bystander to active participant. Circ Res. 2001;89:1111–1121
  27. Sata M, Saiura A, Kunisato A, et al. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med. 2002;8:403–409
  28. Schwartz SM. The intima: a new soil. Circ Res. 1999;85:877–879
  29. Scott NA, Cipolla GD, Ross CE, et al. Identification of a potential role for the adventitia in vascular lesion formation after balloon overstretch injury of porcine coronary arteries. Circulation. 1996;93:2178–2187
  30. Shi Y, O'Brien JE, Fard A, et al. Adventitial myofibroblasts contribute to neointimal formation in injured porcine coronary arteries. Circulation. 1996;94:1655–1664
  31. Shi Y, O'Brien JE, Mannion JD, et al. Remodeling of autologous saphenous vein grafts. The role of perivascular myofibroblasts. Circulation. 1997;95:2684–2693
  32. Shimizu K, Sugiyama S, Aikawa M, et al. Host bone-marrow cells are a source of donor intimal smooth-muscle-like cells in murine aortic transplant arteriopathy. Nat Med. 2001;7:738–741
  33. Simper D, Stalboerger PG, Panetta CJ, et al. Smooth muscle progenitor cells in human blood. Circulation. 2002;106:1199–1204
  34. Stary HC, Chandler AB, Glagov S, et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb. 1994;14:840–856
  35. Werner N, Junk S, Laufs U, et al. Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res. 2003;93:e17–e24
  36. Wilcox JN, Scott NA. Potential role of the adventitia in arteritis and atherosclerosis. Int J Cardiol. 1996;54(Suppl):S21–S35
  37. Xu Q. Mouse models of arteriosclerosis: from arterial injuries to vascular grafts. Am J Pathol. 2004;165:1–10
  38. Xu Q, Zhang Z, Davison F, et al. Circulating progenitor cells regenerate endothelium of vein graft atherosclerosis, which is diminished in apoE-deficient mice. Circ Res. 2003;93:e76–e86
  39. Xu Y, Arai H, Zhuge X, et al. Role of bone marrow-derived progenitor cells in cuff-induced vascular injury in mice. Arterioscler Thromb Vasc Biol. 2004;24:477–482
  40. Yamashima T, Tonchev AB, Vachkov IH, et al. Vascular adventitia generates neuronal progenitors in the monkey hippocampus after ischemia. Hippocampus. 2004;14:861
  41. Zalewski A, Shi Y, Johnson AG. Diverse origin of intimal cells: smooth muscle cells, myofibroblasts, fibroblasts, and beyond?. Circ Res. 2002;91:652–655

PII: S1050-1738(05)00013-7

doi: 10.1016/j.tcm.2005.02.003

Trends in Cardiovascular Medicine
Volume 15, Issue 2 , Pages 64-68 , February 2005

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