Trends in Cardiovascular Medicine
Volume 15, Issue 3 , Pages 86-92, April 2005

Platelet Collagen Receptors and Coagulation. A Characteristic Platelet Response as Possible Target for Antithrombotic Treatment

  • Johan W.M. Heemskerk

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Johan W.M. Heemskerk, PhD Department of Biochemistry, CARIM, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands. Tel.: (+31)43-3881671; fax: (+31)43-3884159.
    • ,
  • Marijke J.E. Kuijpers

      Affiliations

    • These authors contributed equally.
    • ,
  • Imke C.A. Munnix

      Affiliations

    • These authors contributed equally.
    • ,
  • Pia R.M. Siljander

      Affiliations

    • Also address correspondence to: Pia R.M. Siljander, PhD, Department of Biochemistry, University of Cambridge, Downing site, Tennis Court Road, CB2 1QW Cambridge, UK.

Johan W.M. Heemskerk, Marijke J.E. Kuijpers and Imke C.A. Munnix are at the Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, NL. Pia Siljander is at the Department of Biochemistry, University of Cambridge, Cambridge, UK.

Collagen is a unique agonist of platelets, because it acts as an immobilized ligand that only causes platelet activation after stable adhesion. This review addresses the present understanding of how platelet interaction with collagen supports the process of thrombin generation and coagulation. Only some of the collagen-adhered platelets, that is, those showing profound changes in shape and shedding microparticles (resembling apoptotic cells), appear to contribute to the procoagulant activity of platelets. The main signaling receptor for collagen, glycoprotein VI, plays a key role in the platelet procoagulant response during thrombus formation; this is a reason why new anti-glycoprotein-VI antibodies are promising antithrombotic tools.

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PII: S1050-1738(05)00027-7

doi:10.1016/j.tcm.2005.03.003

Trends in Cardiovascular Medicine
Volume 15, Issue 3 , Pages 86-92, April 2005

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