Trends in Cardiovascular Medicine
Volume 15, Issue 3 , Pages 86-92 , April 2005

Platelet Collagen Receptors and Coagulation. A Characteristic Platelet Response as Possible Target for Antithrombotic Treatment

  • Johan W.M. Heemskerk

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Johan W.M. Heemskerk, PhD Department of Biochemistry, CARIM, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands. Tel.: (+31)43-3881671; fax: (+31)43-3884159.
    • ,
  • Marijke J.E. Kuijpers

      Affiliations

    • These authors contributed equally.
    • ,
  • Imke C.A. Munnix

      Affiliations

    • These authors contributed equally.
    • ,
  • Pia R.M. Siljander

      Affiliations

    • Also address correspondence to: Pia R.M. Siljander, PhD, Department of Biochemistry, University of Cambridge, Downing site, Tennis Court Road, CB2 1QW Cambridge, UK.

References 

  1. Andersen H, Greenberg DL, Fujikawa K, et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci USA. 1999;96:11189–11193
  2. Auger JM, Kuijpers MJE, Senis YA, et al. Adhesion of human and mouse platelets to collagen under shear: a unifying model. FASEB J. 2005;(in press)
  3. Béguin S, Kumar R. Thrombin, fibrin and platelets, a resonance loop in which von Willebrand factor is a necessary link. Thromb Haemost. 1997;78:590–594
  4. Bevers EM, Comfurius P, Van Rijn JLML, et al. Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets. Eur J Biochem. 1982;122:429–436
  5. Brooks MB, Catalfamo JL, Brown HA, et al. A hereditary bleeding disorder of dogs caused by a lack of platelet procoagulant activity. Blood. 2002;99:2434–2441
  6. Butenas S, Cawthern KM, Van't Veer C, et al. Antiplatelet agents in tissue factor-induced blood coagulation. Blood. 2001;97:2314–2322
  7. Byzova TV, Plow EF. Networking in the hemostatic system: integrin αIIbβ3 binds prothrombin and influences its activation. J Biol Chem. 1997;272:27183–27188
  8. Chen H, Kahn ML. Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets. Mol Cell Biol. 2003;23:4764–4777
  9. Cosemans JMEM, Kuijpers MJE, Lecut C, et al. Contribution of platelet glycoprotein VI to the thrombogenic effect of collagens in fibrous atherosclerotic lesions. Atherosclerosis. 2005;(in press) DOI:10.1016/j.atherosclerosis.2004.12.037
  10. Dachary-Prigent J, Pasquet JM, Freyssinet JM, Nurden AT. Calcium involvement in aminophospholipid exposure and microparticle formation during platelet activation. Biochemistry. 1995;34:11625–11634
  11. Dale GL, Friese P, Batar P, et al. Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface. Nature. 2001;415:175–179
  12. Day SM, Reeve JL, Pedersen B, et al. Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood. 2005;105:192–198
  13. Engelmann B, Luther T, Müller I. Intravascular tissue factor pathway: a model for rapid initiation of coagulation within the blood vessel. Thromb Haemost. 2003;89:3–8
  14. Falati S, Gross P, Merrill-Skoloff G, et al. Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med. 2002;10:1175–1180
  15. Fox JE, Austin CD, Boyles JK, Steffen PK. Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane. J Cell Biol. 1990;111:483–493
  16. Freyssinet JM. Cellular microparticles: What are they bad or good for?. J Thromb Haemost. 2003;1:1655–1662
  17. Heemskerk JWM, Bevers EM, Lindhout T. Platelet activation and blood coagulation. Thromb Haemost. 2002;88:186–193
  18. Heemskerk JWM, Vuist WMJ, Feijge MAH, et al. Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine and procoagulant activity of adherent platelets. Blood. 1997;90:2615–2625
  19. Hess MW, Siljander P. Procoagulant platelet balloons: Evidence from cryopreparation and electron microscopy. Histochem Cell Biol. 2001;115:439–443
  20. Ilveskero S, Siljander P, Lassila R. Procoagulant activity on platelets adhered to collagen or plasma clot. Arterioscler Thromb Vasc Biol. 2001;21:628–635
  21. Jung SM, Moroi M. Activation of the platelet collagen receptor integrin α2β1. Its mechanism and participation in the physiological functions of platelets. Trends Cardiovasc Med. 2000;10:285–292
  22. Kato K, Kanaji T, Russell S, et al. The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood. 2003;102:1701–1707
  23. Kuijpers MJE, Schulte V, Bergmeier W, et al. Complementary roles of glycoprotein VI and α2β1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J. 2003;17:685–687
  24. Kuijpers MJE, Schulte V, Oury C, et al. Facilitating roles of murine platelet glycoprotein Ib and αIIbβ3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation. J Physiol. 2004;558:403–415
  25. Kulkarni S, Jackson SP. Platelet factor XIII and calpain negatively regulate integrin αIIbβ3 adhesive function and thrombus growth. J Biol Chem. 2004;279:30697–30706
  26. Lecut C, Feeney LA, Kingsbury G, et al. Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments. J Thromb Haemost. 2003;1:2653–2662
  27. Lecut C, Schoolmeester A, Kuijpers MJE, et al. Principal role of glycoprotein VI in α2β1 and αIIbβ3 activation during collagen-induced thrombus formation. Arterioscler Thromb Vasc Biol. 2004;24:1727–1733
  28. Monkovic DD, Tracy PB. Functional characterization of human platelet-released factor V and its inactivation by factor Xa and thrombin. J Biol Chem. 1990;265:17132–17140
  29. Monroe DM, Hoffman M, Roberts HR. Platelets and thrombin generation. Arterioscler Thromb Vasc Biol. 2002;22:1381–1389
  30. Munnix ICA, Harmsma M, Giddings JC, et al. Store-mediated calcium entry in the regulation of phosphatidylserine exposure in blood cells from Scott patients. Thromb Haemost. 2003;89:687–695
  31. Nieswandt B, Brakebusch C, Bergmeier W, et al. Glycoprotein VI but not α2β1 integrin is essential for platelet interaction with collagen. EMBO J. 2001;20:2120–2130
  32. Nieswandt B, Schulte V, Bergmeier W, et al. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. J Exp Med. 2001;193:459–469
  33. Nieswandt B, Watson SP. Platelet-collagen interaction: is GPVI the central receptor?. Blood. 2003;102:449–461
  34. Pasquet JM, Dachary-Prigent J, Nurden AT. Microvesicle release is associated with extensive protein tyrosine dephosphorylation in platelets stimulated by A23187 or a mixture of thrombin and collagen. Biochem J. 1998;333:591–599
  35. Ruggeri ZM, Dent JA, Saldivar E. Contribution of distinct adhesive interactions to platelet aggregation in flowing blood. Blood. 1999;94:172–178
  36. Siess W, Richard R, Penz S, et al. Atherosclerotic plaque core stimulates thrombus formation through the activation of platelet collagen receptors. FASEB J. 2005;(in press)
  37. Siljander P, Carpen O, Lassila R. Platelet-derived microparticles associate with fibrin during thrombosis. Blood. 1996;87:4651–4663
  38. Siljander P, Farndale RW, Feijge MAH, et al. Platelet adhesion enhances the glycoprotein VI-dependent procoagulant response. Arterioscler Thromb Vasc Biol. 2001;21:618–627
  39. Siljander P, Lassila R. Studies of adhesion-dependent platelet activation: distinct roles for different participating receptors can be dissociated by proteolysis of collagen. Arterioscler Thromb Vasc Biol. 1999;19:3033–3043
  40. Siljander PRM, Munnix ICA, Smethurst PA, et al. Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood. Blood. 2004;103:1333–1341
  41. Sims PJ, Wiedmer T, Esmon CT, et al. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane: studies in Scott syndrome, an isolated defect in platelet procoagulant activity. J Biol Chem. 1989;264:17049–17057
  42. Smethurst PA, Joutsi-Korhonen L, O'Connor MN, et al. Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. Blood. 2004;103:903–911
  43. Wolf BB, Goldstein JC, Stennicke HR, et al. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood. 1999;94:1683–1692
  44. Wu YP, Vink T, Schiphorst M, et al. Platelet thrombus formation on collagen at high shear rates is mediated by von Willebrand factor–glycoprotein Ib interaction and inhibited by von Willebrand factor–glycoprotein IIb/IIIa interaction. Arterioscler Thromb Vasc Biol. 2000;20:1661–1667
  45. Zaman GJR, Conway EM. The elusive factor Xa receptor: failure to detect transcripts that correspond to the published sequence of EPR1. Blood. 2000;96:145–148
  46. Zwaal RFA, Comfurius P, Smeets E, et al. Platelet procoagulant activity and microvesicle formation. In:  Seghatchian MJ,  Samama MM,  Hecker SP editor. Hypercoagulable states. Boca Raton, FL: CRC Press; 1996;p. 29–36
  47. Zwaal RFA, Schroit AJ. Pathophysiological implications of membrane phospholipid asymmetry in blood cells. Blood. 1997;89:1121–1132

PII: S1050-1738(05)00027-7

doi: 10.1016/j.tcm.2005.03.003

Trends in Cardiovascular Medicine
Volume 15, Issue 3 , Pages 86-92 , April 2005

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