Trends in Cardiovascular Medicine
Volume 15, Issue 5 , Pages 174.e1-174.e24 , July 2005

Endothelial Cell Gene Regulation

  • Takashi Minami
    • ,
  • William C. Aird

      Affiliations

    • Corresponding Author InformationAddress correspondence to: William C. Aird, MD, Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, RW-663, 330 Brookline Avenue, Boston, MA 02215, USA. Tel.: (+1) 617-667-1031; fax: (+1) 617-667-1035

References 

  1. Aird WC. Endothelial cell heterogeneity. Crit Care Med. 2003;31:S221–S230
  2. Aird WC. Targeting the endothelium in sepsis and multiorgan dysfunction. Sci Med. 2003;9:108–119
  3. Aird WC, Edelberg JM, Weiler-Guettler H, et al. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol. 1997;138:1117–1124
  4. Aird WC, Jahroudi N, Weiler-Guettler H, et al. Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice. Proc Natl Acad Sci USA. 1995;92:4567–4571
  5. Aitsebaomo J, Kingsley-Kallesen ML, Wu Y, et al. Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter. J Biol Chem. 2001;276:39197–39205
  6. Arap W, Kolonin MG, Trepel M, et al. Steps toward mapping the human vasculature by phage display. Nat Med. 2002;8:121–127
  7. Chi JT, Chang HY, Haraldsen G, et al. Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci USA. 2003;100:10623–10628
  8. Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 1998;91:3527–3561
  9. Contrino J, Hair G, Kreutzer DL, Rickles FR. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med. 1996;2:209–215
  10. Crawley J, Lupu F, Westmuckett AD, et al. Expression, localization, and activity of tissue factor pathway inhibitor in normal and atherosclerotic human vessels. Arterioscler Thromb Vasc Biol. 2000;20:1362–1373
  11. Drake TA, Cheng J, Chang A, Taylor FB. Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. Am J Pathol. 1993;142:1458–1470
  12. Edelberg JM, Tang L, Hattori K, et al. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res. 2002;90:E89–E93
  13. Evans V, Hatzopoulos A, Aird WC, et al. Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics. 2000;2:67–75
  14. Guillot PV, Liu L, Kuivenhoven JA, et al. Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression. Physiol Genomics. 2000;2:77–83
  15. Hatley ME, Srinivasan S, Reilly KB, et al. Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice. J Biol Chem. 2003;278:25369–25375
  16. Kumar S, West DC, Ager A. Heterogeneity in endothelial cells from large vessels and microvessels. Differentiation. 1987;36:57–70
  17. Lacorre DA, Baekkevold ES, Garrido I, et al. Plasticity of endothelial cells: rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment. Blood. 2004;103:4164–4172
  18. Minami T, Donovan DJ, Tsai JC, et al. Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice. Blood. 2002;100:4019–4025
  19. Minami T, Kuivenhoven JA, Evans V, et al. Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice. Arterioscler Thromb Vasc Biol. 2003;23:2041–2047
  20. Nachman RL, Jaffe EA. Endothelial cell culture: beginnings of modern vascular biology. J Clin Invest. 2004;114:1037–1040
  21. Nagayasu T, Saadi S, Holzknecht RA, et al. Expression of tissue factor mRNA in cardiac xenografts: clues to the pathogenesis of acute vascular rejection. Transplantation. 2000;69:475–482
  22. Oh P, Li Y, Yu J, et al. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature. 2004;429:629–635
  23. Page C, Rose M, Yacoub M, Pigott R. Antigenic heterogeneity of vascular endothelium. Am J Pathol. 1992;141:673–683
  24. Reese TS, Karnovsky MJ. Fine structural localization of a blood–brain barrier to exogenous peroxidase. J Cell Biol. 1967;34:207–217
  25. Schlaeger TM, Bartunkova S, Lawitts JA, et al. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice. Proc Natl Acad Sci USA. 1997;94:3058–3063
  26. Schlaeger TM, Qin Y, Fujiwara Y, et al. Vascular endothelial cell lineage-specific promoter in transgenic mice. Development. 1995;121:1089–1098
  27. Solovey A, Kollander R, Shet A, et al. Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatin. Blood. 2004;104:840–846
  28. Turner RR, Beckstead JH, Warnke RA, Wood GS. Endothelial cell phenotypic diversity. In situ demonstration of immunologic and enzymatic heterogeneity that correlates with specific morphologic subtypes. Am J Clin Pathol. 1987;87:569–575
  29. Xiong JW, Leahy A, Lee HH, Stuhlmann H. Vezf1: a Zn finger transcription factor restricted to endothelial cells and their precursors. Dev Biol. 1999;206:123–141

PII: S1050-1738(05)00083-6

doi: 10.1016/j.tcm.2005.06.002

Trends in Cardiovascular Medicine
Volume 15, Issue 5 , Pages 174.e1-174.e24 , July 2005

Article Tools

* Image Usage & Resolution