Trends in Cardiovascular Medicine
Volume 16, Issue 2 , Pages 35-38 , February 2006

Integration—A Key to Success in the Genetic Dissection of Complex Diseases?

  • Yoram Yagil

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Yoram Yagil, MD, FAHA, Department of Nephrology and Hypertension, Laboratory for Molecular Medicine and Israeli Rat Genome Center, Faculty of Health Sciences, Ben-Gurion University, Barzilai Medical Center Campus, Ashkelon 78306, Israel. Tel.: (+972) 8-6745885; fax: (+972) 8-6745824.
    • ,
  • Chana Yagil

References 

  1. Cowley AW, Liang M, Roman RJ, et al. Consomic rat model systems for physiological genomics. Acta Physiol. Scand. 2004;181:585–592
  2. Cowley AW, Roman RJ, Jacob HJ. Application of chromosomal substitution techniques in gene-function discovery. J. Physiol. 2004;554:46–55
  3. Garrett MR, Rapp JP. Defining the blood pressure QTL on Chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1. Mamm. Genome. 2003;14:268–273
  4. Hubner N, Wallace CA, Zimdahl H, et al. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat. Genet. 2005;37:243–253
  5. Lander E, Kruglyak L. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat. Genet. 1995;11:241–247
  6. Liang M, Cowley AW, Hessner MJ, et al. Transcriptome analysis and kidney research: Toward systems biology. Kidney Int. 2005;67:2114–2122
  7. Yagil Y, Yagil C. Congenics in the pathway from quantitative trait loci detection to gene identification: Is that the way to go?. J. Hypertens. 2003;21:2009–2011
  8. Yagil Y, Yagil C. The search for the genetic basis of hypertension. Curr. Opin. Nephrol. Hypertens. 2005;14:141–147
  9. Yagil C, Katni G, Rubattu S, et al. Development, genotype and phenotype of a new colony of the Sabra hypertension prone (SBH/y) and resistant (SBN/y) rat model of salt sensitivity and resistance. J. Hypertens. 1996;14:1175–1182
  10. Yagil C, Sapojnikov M, Kreutz R, et al. Salt susceptibility maps to Chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension. Hypertension. 1998;31:119–124
  11. Yagil C, Hubner N, Kreutz R, et al. Congenic strains confirm the presence of salt-sensitivity QTLs on Chromosome 1 in the Sabra rat model of hypertension. Physiol. Genomics. 2003;12:85–95
  12. Yagil C, Hubner N, Monti J, et al. Identification of hypertension-related genes through an integrated genomic–transcriptomic approach. Circ. Res. 2005;96:617–625

PII: S1050-1738(05)00215-X

doi: 10.1016/j.tcm.2005.11.001

Trends in Cardiovascular Medicine
Volume 16, Issue 2 , Pages 35-38 , February 2006

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