Trends in Cardiovascular Medicine
Volume 16, Issue 2 , Pages 60-64, February 2006

Atherosclerosis and the Lectin-like OXidized Low-Density Lipoprotein Scavenger Receptor

Leeds Vascular Institute, The General Infirmary at Leeds, Great George Street, Leeds, UK, LS1 3EX

Endothelial Cell Biology Unit, Faculty of Biological Science, University of Leeds, Leeds, UK, LS2 9JT

The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization. LOX-1 levels are elevated upon recognition of oxidized low-density lipoprotein, a key pro-atherogenic substance in the vasculature. Recent evidence indicates this gene product is a biomarker of inflammation and disease status. We review and assess the role of LOX-1 in atherosclerotic plaque formation, physiologic regulation, and as a biomarker and target in cardiovascular disease diagnosis and prevention.

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PII: S1050-1738(05)00223-9

doi:10.1016/j.tcm.2005.12.001

Trends in Cardiovascular Medicine
Volume 16, Issue 2 , Pages 60-64, February 2006

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