Trends in Cardiovascular Medicine
Volume 16, Issue 4 , Pages 103-108, May 2006

SDF-1α-Mediated Tissue Repair by Stem Cells: A Promising Tool in Cardiovascular Medicine?

Division of Cardiology, Medizinische Poliklinik-Innenstadt, University of Munich

Department for Cardiovascular Research, University Hospital, RWTH Aachen, Germany

Circulating smooth muscle progenitor cells have been identified as a source for neointimal smooth muscle cells after various types of injuries to the vessel wall contributing to neointimal hyperplasia, implying a fundamental role of these progenitor cells in the vascular response to injury. Recent studies have provided insight into the molecular mechanisms of mobilization and local recruitment of smooth muscle progenitor cells. The CXC chemokine SDF-1α and its receptor CXCR4 have been identified as the central signaling axis regulating the homing of smooth muscle progenitor cells into the injured vessel wall. This review discusses the unique biologic functions of this chemokine and its contribution to stem-cell-based vascular repair and disease.

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PII: S1050-1738(06)00019-3

doi:10.1016/j.tcm.2006.01.006

Trends in Cardiovascular Medicine
Volume 16, Issue 4 , Pages 103-108, May 2006

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