Trends in Cardiovascular Medicine
Volume 16, Issue 5 , Pages 177-182 , July 2006

Alternatively Spliced Tissue Factor: A Previously Unknown Piece in the Puzzle of Hemostasis

  • Björn Szotowski
    • ,
  • Silvio Antoniak
    • ,
  • Ursula Rauch

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Ursula Rauch, MD, Medical Clinic II, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D-12200 Berlin, Germany. Tel.: (+49) 30-8445-2362; fax: (+49) 30-8441-9991.

References 

  1. Banner DW, D'Arcy A, Chene C, et al. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature. 1996;380:41–46
  2. Barron C, Migliaccio AR, Migliaccio G, et al. Alternatively spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell lines and bone marrow. Gene. 1994;147:263–268
  3. Baumann G, Shaw MA, Buchanan TA. In vivo kinetics of a covalent growth hormone-binding protein complex. Metabolism. 1989;38:330–333
  4. Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci U S A. 1990;87:6934–6938
  5. Belting M, Ahamed J, Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol. 2005;25:1545–1550
  6. Beuneu C, Vosters O, Movahedi B, et al. Human pancreatic duct cells exert tissue factor-dependent procoagulant activity: relevance to islet transplantation. Diabetes. 2004;53:1407–1411
  7. Bogdanov VY, Balasubramanian V, Hathcock J, et al. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med. 2003;9:458–462
  8. Bogdanov VY, Kirk RI, Miller C, et al. Identification and characterization of murine alternatively spliced tissue factor. J Thromb Haemost. 2006;4:158–167
  9. Butenas S, Mann KG. Active tissue factor in blood?. Nat Med. 2004;10:1155–1156
  10. Carey MJ, Rodgers GM. Disseminated intravascular coagulation: clinical and laboratory aspects. Am J Hematol. 1998;59:65–73
  11. Chand HS, Ness SA, Kisiel W. Identification of a novel human tissue factor splice variant that is upregulated in tumor cells. Int J Cancer. 2006;118:1713–1720
  12. Dastot F, Sobrier ML, Duquesnoy P, et al. Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein. Proc Natl Acad Sci U S A. 1996;93:10723–10728
  13. Edgington TS, Mackman N, Brand K, et al. The structural biology of expression and function of tissue factor. Thromb Haemost. 1991;66:67–79
  14. Eilertsen KE, Osterud B. Tissue factor: (patho)physiology and cellular biology. Blood Coagul Fibrinolysis. 2004;15:521–538
  15. Fleck RA, Rao LV, Rapaport SI, et al. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb Res. 1990;59:421–437
  16. Fuh G, Wells JA. Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. J Biol Chem. 1995;270:13133–13137
  17. Giesen PL, Rauch U, Bohrmann B, et al. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci U S A. 1999;96:2311–2315
  18. Harlos K, Martin DM, O'Brien DP, et al. Crystal structure of the extracellular region of human tissue factor. Nature. 1994;370:662–666
  19. Hathcock J. Vascular biology—the role of tissue factor. Semin Hematol. 2004;41:30–34
  20. Heaney ML, Golde DW. Soluble cytokine receptors. Blood. 1996;87:847–857
  21. Lee BP, Rushlow WJ, Chakraborty C, et al. Differential gene expression in premalignant human trophoblast: role of IGFBP-5. Int J Cancer. 2001;94:674–684
  22. Mallat Z, Benamer H, Hugel B, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation. 2000;101:841–843
  23. Muller YA, Ultsch MH, Kelley RF, et al. Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. Biochemistry. 1994;33:10864–10870
  24. Nemerson Y. Tissue factor: then and now. Thromb Haemost. 1995;74:180–184
  25. Osterud B, Bjorklid E. The tissue factor pathway in disseminated intravascular coagulation. Semin Thromb Hemost. 2001;27:605–617
  26. Petersen LC, Thastrup O, Hagel G, et al. Exclusion of known protease-activated receptors in factor VIIa-induced signal transduction. Thromb Haemost. 2000;83:571–576
  27. Poulsen LK, Jacobsen N, Sorensen BB, et al. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor. J Biol Chem. 1998;273:6228–6232
  28. Rauch U, Nemerson Y. Circulating tissue factor and thrombosis. Curr Opin Hematol. 2000;7:273–277
  29. Rauch U, Nemerson Y. Tissue factor, the blood, and the arterial wall. Trends Cardiovasc Med. 2000;10:139–143
  30. Rauch U, Bonderman D, Bohrmann B, et al. Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor. Blood. 2000;96:170–175
  31. Rauch U, Osende JI, Fuster V, et al. Thrombus formation on atherosclerotic plaques: pathogenesis and clinical consequences. Ann Intern Med. 2001;134:224–238
  32. Rauch U, Antoniak S, Boots M, et al. Association of tissue-factor upregulation in squamous-cell carcinoma of the lung with increased tissue factor in circulating blood. Lancet Oncol. 2005;6:254
  33. Rose-John S, Heinrich PC. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J. 1994;300:281–290(pt 2)
  34. Ruf W, Kalnik MW, Lund-Hansen T, et al. Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions. J Biol Chem. 1991;266:15719–15725
  35. Ruf W, Rehemtulla A, Morrissey JH, et al. Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function. J Biol Chem. 1991;266:2158–2166
  36. Sambola A, Osende J, Hathcock J, et al. Role of risk factors in the modulation of tissue factor activity and blood thrombogenicity. Circulation. 2003;107:973–977
  37. So AK, Varisco PA, Kemkes-Matthes B, et al. Arthritis is linked to local and systemic activation of coagulation and fibrinolysis pathways. J Thromb Haemost. 2003;1:2510–2515
  38. Sorensen BB, Rao LV. Interaction of activated factor VII and active site-inhibited activated factor VII with tissue factor. Blood Coagul Fibrinolysis. 1998;9:S67–S71(suppl 1)
  39. Steinhoff M, Buddenkotte J, Shpacovitch V, et al. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev. 2005;26:1–43
  40. Szotowski B, Antoniak S, Poller W, et al. Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines. Circ Res. 2005;96:1233–1239
  41. Szotowski B, Goldin-Lang P, Antoniak S, et al. Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy. J Am Coll Cardiol. 2005;45:1081–1089
  42. Versteeg HH, Spek CA, Peppelenbosch MP, et al. Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways. Mol Med. 2004;10:6–11
  43. Watanabe T, Yasuda M, Yamamoto T. Angiogenesis induced by tissue factor in vitro and in vivo. Thromb Res. 1999;96:183–189
  44. Waxman E, Ross JB, Laue TM, et al. Tissue factor and its extracellular soluble domain: the relationship between intermolecular association with factor VIIa and enzymatic activity of the complex. Biochemistry. 1992;31:3998–4003
  45. Yu JL, Rak JW. Shedding of tissue factor (TF)-containing microparticles rather than alternatively spliced TF is the main source of TF activity released from human cancer cells. J Thromb Haemost. 2004;2:2065–2067
  46. Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood. 1997;89:1121–1132

PII: S1050-1738(06)00049-1

doi: 10.1016/j.tcm.2006.03.005

Trends in Cardiovascular Medicine
Volume 16, Issue 5 , Pages 177-182 , July 2006

Article Tools

* Image Usage & Resolution