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Trends in Cardiovascular Medicine
Volume 16, Issue 6
, Pages 193-198
, August 2006
Role of Homeodomain-Only Protein in the Cardiac Conduction System
References
- A targeted disruption in connexin40 leads to distinct atrioventricular conduction defects. J. Interv. Card. Electrophysiol. 2000;4:459–467
- Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. J. Clin. Invest. 1999;104:1567–1573
- Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain–DNA complex. J. Mol. Biol. 1993;234:1084–1093
- Wnt11 and Wnt7a are up-regulated in association with differentiation of cardiac conduction cells in vitro and in vivo. Dev. Dyn. 2002;227:536–543
- A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001;106:709–721
- . Recruitment of the tinman homolog Nkx2-5 by serum response factor activates cardiac alpha-actin genes. Mol. Cell. Biol. 1996;16:6372–6384
- Hop is an unusual homeobox gene that modulates cardiac development. Cell. 2002;110:713–723
- Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage. Development. 1999;126:5041–5049
- T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 2004;229:763–770
- . Understanding conduction system development: A hop, skip and jump away?. Circ. Res. 2005;96:809–811
- Divergent expression of delayed rectifier K+ channel subunits during mouse heart development. Cardiovasc. Res. 2001;52:65–75
- . On the innervation of the heart, with a special reference to the heart of the tortoise. J. Physiol. 1883;4:43
- Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system. Development. 1995;121:1423–1431
- Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers. Proc. Natl. Acad. Sci. U. S. A. 1998;95:6815–6818
- TBX5 transcription factor regulates cell proliferation during cardiogenesis. Dev. Biol. 2001;230:177–188
- Tbx5 associates with Nkx2.5 and synergistically promotes cardiomyocyte differentiation. Nat. Genet. 2001;28:276–280
- The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovasc. Res. 2004;62:489–499
- . Effects of race and health insurance on the rates of pacemaker implantation for complete heart block in the United States. Am. J. Cardiol. 2004;94:227–229
- Homeobox protein Hop functions in the adult cardiac conduction system. Circ. Res. 2005;96:898–903
- Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J. Clin. Invest. 2004;113:1130–1137
- Crystal structure of an engrailed homeodomain–DNA complex at 2.8Å resolution: A framework for understanding homeodomain–DNA interactions. Cell. 1990;63:579–590
- Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J. Clin. Invest. 2003;112:863–871
- Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ. Res. 1999;84:146–152
- . Homeodomains bind related targets in DNA. In: Genes VIII. New York: Oxford University; 2004;p. 647–649
- Nkx-2.5, a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development. 1993;119:419–431
- . The paradoxical text ‘On the Heart’. I. Med. Hist. 1973;17:1–15
- Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes Dev. 1995;9:1654–1666
- The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development. 2004;131:4107–4116
- Nkx2-5 pathways and congenital heart disease: Loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell. 2004;117:378–386
- . Endothelin-1 and neuregulin-1 convert embryonic cardiomyocytes into cells of the conduction system in the mouse. Dev. Dyn. 2005;233:20–28
- Haploinsufficiency in combination with aging causes SCN5A-linked hereditary Lenegre disease. J. Am. Coll. Cardiol. 2003;41:643–652
- Visualization and functional characterization of the developing murine cardiac conduction system. Development. 2001;128:1785–1792
- Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc. Natl. Acad. Sci. U. S. A. 2002;99:10464–10469
- Mouse model of SCN5A-linked hereditary Lenègre's disease: Age-related conduction slowing and myocardial fibrosis. Circulation. 2005;111:1738–1746
- Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science. 1998;281:108–111
- Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system. Anat. Rec. 2003;274A:773–777
- Modulation of cardiac development by HOP, an unusual homeodomain protein. Cell. 2002;110:725–735
- The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development. 1999;126:1269–1280
- . Das Reizleitungssystem des Herzens. Jena: Gustav Fischer; 1906;
- Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40. J. Cardiovasc. Electrophysiol. 1999;10:1380–1389
PII: S1050-1738(06)00052-1
doi: 10.1016/j.tcm.2006.03.009
© 2006 Elsevier Inc. All rights reserved.
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Trends in Cardiovascular Medicine
Volume 16, Issue 6
, Pages 193-198
, August 2006
