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Trends in Cardiovascular Medicine
Volume 16, Issue 7
, Pages 217-220
, October 2006
Hedgehog Turns Lipoproteins Into Janus-Faced Particles
References
- The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell. 1996;86:221–232
- . Hedgehog: an unusual signal transducer. Bioessays. 2004;26:387–394
- . Hedgehog signaling: from the Drosophila cuticle to anti-cancer drugs. Dev Cell. 2005;8:143–151
- . In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development. 1998;125:4943–4948
- . Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell. 2000;102:521–531
- Synergistic and antagonistic roles of the sonic hedgehog N- and C-terminal lipids. Development. 2004;131:4357–4370
- . Developmental cell biology: communicating with hedgehogs. Nat Rev Mol Cell Biol. 2005;6:306–317
- Receptor-mediated endocytosis of soluble and membrane-tethered sonic hedgehog by Patched-1. Proc Natl Acad Sci U S A. 2000;97:12044–12049
- . Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Curr Biol. 2002;12:983–995
- . Role of the Drosophila patched gene in positional signalling. Nature. 1991;353:184–187
- . Cholesterol modification of hedgehog family proteins. J Clin Invest. 2002;110:591–596
- Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic. Arterioscler Thromb Vasc Biol. 2004;24:2102–2107
- Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med. 2005;11:1197–1204
- Biochemical evidence that patched is the Hedgehog receptor. Nature. 1996;384:176–179
- The comparative pathobiology of atherosclerosis and restenosis. Am J Cardiol. 2005;86:6H–11H
- Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature. 2005;435:58–65
- Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem. 1998;273:14037–14045
- The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med. 2001;7:706–711
- Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia. Circulation. 2003;108:479–485
- . Cholesterol modification of hedgehog signaling proteins in animal development. Science. 1996;274:255–259
- . The morphogen sonic hedgehog collaborates with netrin-1 to guide axons in the spinal cord. Trends Neurosci. 2003;26:641–643
- . Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4+ T cells. J Immunol. 2002;169:5451–5457
- . FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature. 2005;435:172–177
- Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet. 2004;36:277–282
- . Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature. 1996;382:547–551
- . Insect lipoprotein follows a transferrin-like recycling pathway that is mediated by the insect LDL receptor homologue. J Cell Sci. 2002;115:4001–4012
PII: S1050-1738(06)00068-5
doi: 10.1016/j.tcm.2006.04.002
© 2006 Elsevier Inc. All rights reserved.
« Previous
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Trends in Cardiovascular Medicine
Volume 16, Issue 7
, Pages 217-220
, October 2006
