« Previous
Next »
Trends in Cardiovascular Medicine
Volume 16, Issue 7
, Pages 220-234
, October 2006
In Search of New Targets for Plasma High-Density Lipoprotein Cholesterol Levels: Promise of Human–Mouse Comparative Genomics
References
- A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population. Atherosclerosis. 2005;181:389–397
- . Clinical practice. Low HDL cholesterol levels. N Engl J Med. 2005;353:1252–1260
- . Emerging role of high-density lipoprotein in the prevention of cardiovascular disease. Drug Discov Today. 2005;10:1095–1101
- . Haplotype-based genetics in mice and rats. Trends Genet. 2005;21:318–322
- . Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet. 1998;18:19–24
- Evidence for a gene influencing high-density lipoprotein cholesterol on chromosome 4q31.21. Arterioscler Thromb Vasc Biol. 2006;26:392–397
- . Bioinformatics toolbox for narrowing rodent quantitative trait loci. Trends Genet. 2005;21:683–692
- Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med. 2004;350:29–37
- . Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet. 2005;6:271–286
- Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia. Hum Genet. 2005;117:494–505
- Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder. Mol Psychiatry. 2004;9:474–484
- High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation. 1989;79:8–15
- Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions. Eur J Hum Genet. 2005;13:1143–1153
- Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet. 2005;37:835–843
- Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene, POMC. J Clin Endocrinol Metab. 1999;84:3187–3191
- . Genetic regulation of bone mineral density in mice. J Musculoskelet Neuronal Interact. 2002;2:232–236
- . Unraveling the genetics of chronic kidney disease using animal models. Am J Physiol Renal Physiol. 2004;287:F347–F352
- Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 1998;19:155–157
- A novel quantitative trait locus on chromosome 1 with pleiotropic effects on HDL-cholesterol and LDL particle size in hypertensive sibships. Am J Hypertens. 2005;18:1084–1090
- . Analysis of quantitative lipid traits in the genetics of NIDDM (GENNID) study. Diabetes. 2005;54:3007–3014
- Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Oncogene. 2004;23:4495–4504
- . Raising HDL cholesterol. Nat Rev Drug Discov. 2005;4:185–186
- Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes. 2004;53:2676–2683
- . Multiple cross and inbred strain haplotype mapping of complex-trait candidate genes. Genome Res. 2003;13:118–121
- New target regions for human hypertension via comparative genomics. Genome Res. 2000;10:473–482
- Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene. Genetics. 2006;172:1799–1807
- Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics. 2001;71:70–77
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 2003;423:506–511
- . Quantitative trait loci and candidate genes regulating HDL cholesterol: a murine chromosome map. Arterioscler Thromb Vasc Biol. 2002;22:1390–1401
- . Genetics of variation in HDL cholesterol in humans and mice. Circ Res. 2005;96:27–42
- . Genome-wide search for new genes controlling plasma lipid concentrations in mice and humans. Curr Opin Lipidol. 2005;16:127–137
- Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci. Genome Res. 2003;13:1654–1664
- . Haplotype analysis in multiple crosses to identify a QTL gene. Genome Res. 2004;14:1767–1772
- Identifying novel genes for atherosclerosis through mouse–human comparative genetics. Am J Hum Genet. 2005;77:1–15
- Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet. 2005;37:365–372
- Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. J Lipid Res. 2005;46:1416–1425
- Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia. J Lipid Res. 2005;46:2202–2213
PII: S1050-1738(06)00069-7
doi: 10.1016/j.tcm.2006.04.003
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
Trends in Cardiovascular Medicine
Volume 16, Issue 7
, Pages 220-234
, October 2006
