Trends in Cardiovascular Medicine
Volume 16, Issue 7 , Pages 240-245, October 2006

The Role of Smad3-Dependent TGF-β Signal in Vascular Response to Injury

  • Koutaro Yokote

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Koutaro Yokote, MD, PhD, DMSci, Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Tel: (+81) 43 222 7171x5257; fax: (+81) 43 226 2095.
    • ,
  • Kazuki Kobayashi
    • ,
  • Yasushi Saito

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Chiba, Japan

Transforming growth factor (TGF)-β is a multifunctional cytokine involved in the regulation of proliferation, differentiation, migration, and survival of many different cell types. The role of TGF-β in atherosclerosis has been intensively studied, but the precise function of the downstream signals in this disease entity remains unclear. We recently discovered that mice lacking Smad3, a major downstream mediator of TGF-β, show enhanced neointimal hyperplasia with decreased matrix deposition in response to vascular injury. This review summarizes the current view on involvement of TGF-β in atherosclerotic vascular disease and discusses the role of Smad3-dependent TGF-β signal in vascular response to injury.

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PII: S1050-1738(06)00071-5

doi:10.1016/j.tcm.2006.04.005

Trends in Cardiovascular Medicine
Volume 16, Issue 7 , Pages 240-245, October 2006

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