Trends in Cardiovascular Medicine
Volume 17, Issue 1 , Pages 5-10 , January 2007

Activated αvβ3 Integrin Targeting in Injury-Induced Vascular Remodeling

  • Mehran M. Sadeghi

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Mehran M. Sadeghi, MD, VA Connecticut Healthcare System, 950 Campbell Avenue, 111B, West Haven, CT 06516, USA. Tel.: (+1) 203-932-5711x3398; fax: (+1) 203-937-3884.
  • ,
  • Jeffrey R. Bender

References 

  1. Blankenberg FG, Strauss HW. Nuclear medicine applications in molecular imaging. J Magn Reson Imaging. 2002;16:352–361
  2. Byzova TV, Plow EF. Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin. J Cell Biol. 1998;143:2081–2092
  3. Chico TJ, Chamberlain J, Gunn J, et al. Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty. Circulation. 2001;103:1135–1141
  4. Elmaleh DR, Narula J, Babich JW, et al. Rapid noninvasive detection of experimental atherosclerotic lesions with novel 99mTc-labeled diadenosine tetraphosphates. Proc Natl Acad Sci U S A. 1998;95:691–695
  5. Faxon DP. Predicting restenosis: bigger is better but not best. Circulation. 2000;101:946–947
  6. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res. 2002;90:251–262
  7. Harris TD, Kalogeropoulos S, Nguyen T, et al. Design, synthesis, and evaluation of radiolabeled integral αvβ3 receptor antagonists for tumor imaging and radiotherapy. Cancer Biother Radiopharm. 2003;18:627–641
  8. Haubner R, Wester HJ. Radiolabeled tracers for imaging of tumor angiogenesis and evaluation of anti-angiogenic therapies. Curr Pharm Des. 2004;10:1439–1455
  9. Haubner R, Wester HJ, Reuning U, et al. Radiolabeled alpha(v)beta3 integrin antagonists: a new class of tracers for tumor targeting. J Nucl Med. 1999;40:1061–1071
  10. Haubner R, Wester HJ, Burkhart F, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001;42:326–336
  11. Haubner R, Wester HJ, Weber WA, et al. Noninvasive imaging of αvβ3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res. 2001;61:1781–1785
  12. Hoshiga M, Alpers CE, Smith LL, et al. Alpha-v beta-3 integrin expression in normal and atherosclerotic artery. Circ Res. 1995;77:1129–1135
  13. Hua J, Dobrucki LW, Sadeghi MM, et al. Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia. Circulation. 2005;111:3255–3260
  14. Humphries MJ. Integrin activation: the link between ligand binding and signal transduction. Curr Opin Cell Biol. 1996;8:632–640
  15. Johnson LL, Schofield LM, Verdesca SA, et al. In vivo uptake of radiolabeled antibody to proliferating smooth muscle cells in a swine model of coronary stent restenosis. J Nucl Med. 2000;41:1535–1540
  16. Kanda S, Kuzuya M, Ramos MA, et al. Matrix metalloproteinase and alphavbeta3 integrin-dependent vascular smooth muscle cell invasion through a type I collagen lattice. Arterioscler Thromb Vasc Biol. 2000;20:998–1005
  17. Kiosses WB, Shattil SJ, Pampori N, Schwartz MA. Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol. 2001;3:316–320
  18. Koyama N, Seki J, Vergel S, et al. Regulation and function of an activation-dependent epitope of the beta 1 integrins in vascular cells after balloon injury in baboon arteries and in vitro. Am J Pathol. 1996;148:749–761
  19. Liu L, Schwartz BR, Tupper J, et al. The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion. J Biol Chem. 2002;277:40893–40900
  20. Mari C, Strauss HW. Radiotracer characterization of coronary artery lesions. Nucl Med Commun. 2002;23:703–706
  21. Meding J, Dinkelborg LM, Grieshaber MK, Semmler W. Targeting of endothelin receptors for molecular imaging of atherosclerosis in rabbits. J Nucl Med. 2002;43:400–405
  22. Meoli DF, Sadeghi MM, Krassilnikova S, et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest. 2004;113:1684–1691
  23. Moiseeva EP. Adhesion receptors of vascular smooth muscle cells and their functions. Cardiovasc Res. 2001;52:372–386
  24. Narula J, Strauss HW. Predicting the likelihood of postangioplastic restenosis: a proliferating challenge for nuclear medicine. J Nucl Med. 2000;41:1541–1544
  25. Narula J, Petrov A, Bianchi C, et al. Noninvasive localization of experimental atherosclerotic lesions with mouse/human chimeric Z2D3 F(ab')2 specific for the proliferating smooth muscle cells of human atheroma. Imaging with conventional and negative charge-modified antibody fragments. Circulation. 1995;92:474–484
  26. O'Toole TE, Katagiri Y, Faull RJ, et al. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol. 1994;124:1047–1059
  27. Pampori N, Hato T, Stupack DG, et al. Mechanisms and consequences of affinity modulation of integrin αvβ3 detected with a novel patch-engineered monovalent ligand. J Biol Chem. 1999;274:21609–21616
  28. Sadeghi MM, Krassilnikova S, Zhang J, et al. Detection of injury-induced vascular remodeling by targeting activated αvβ3 integrin in vivo. Circulation. 2004;110:84–90
  29. Sajid M, Stouffer GA. The role of αvβ3 integrins in vascular healing. Thromb Haemost. 2002;87:187–193
  30. Schafers M, Riemann B, Kopka K, et al. Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivo. Circulation. 2004;109:2554–2559
  31. Shattil SJ. Function and regulation of the beta 3 integrins in hemostasis and vascular biology. Thromb Haemost. 1995;74:149–155
  32. Sipkins DA, Cheresh DA, Kazemi MR, et al. Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging. Nat Med. 1998;4:623–626
  33. Srivatsa SS, Fitzpatrick LA, Tsao PW, et al. Selective αvβ3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury: evidence for the functional importance of integrin αvβ3 and osteopontin expression during neointima formation. Cardiovasc Res. 1997;36:408–428
  34. Stouffer GA, Hu Z, Sajid M, et al. Beta3 integrins are upregulated after vascular injury and modulate thrombospondin- and thrombin-induced proliferation of cultured smooth muscle cells. Circulation. 1998;97:907–915
  35. Takagi J, Petre BM, Walz T, Springer TA. Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell. 2002;110:599–611
  36. Tepe G, Duda SH, Meding J, et al. Tc-99m-labeled endothelin derivative for imaging of experimentally induced atherosclerosis. Atherosclerosis. 2001;157:383–392
  37. Tzima E, Del Pozo MA, Shattil SJ, et al. Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. EMBO J. 2001;20:4639–4647
  38. Van der Zee R, Murohara T, Passeri J, et al. Reduced intimal thickening following αvβ3 blockade is associated with smooth muscle cell apoptosis. Cell Adhes Commun. 1998;6:371–379
  39. Winter PM, Morawski AM, Caruthers SD, et al. Molecular imaging of angiogenesis in early-stage atherosclerosis with αvβ3-integrin-targeted nanoparticles. Circulation. 2003;108:2270–2274
  40. Zhang J, Krassilnikova S, Gharaei AA, et al. Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study. FASEB J. 2005;19:1857–1859
  41. Zhu Q, Piao D, Sadeghi MM, Sinusas AJ. Simultaneous optical coherence tomography imaging and beta particle detection. Opt Lett. 2003;28:1704–1706

PII: S1050-1738(06)00115-0

doi: 10.1016/j.tcm.2006.07.003

Trends in Cardiovascular Medicine
Volume 17, Issue 1 , Pages 5-10 , January 2007