Trends in Cardiovascular Medicine
Volume 17, Issue 1 , Pages 19-25 , January 2007

The Regulation of the Inflammatory Response Through Nuclear Factor-κB Pathway by Angiotensin IV Extends the Role of the Renin Angiotensin System in Cardiovascular Diseases

  • Marta Ruiz-Ortega

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Marta Ruiz-Ortega, Vascular and Renal Research Laboratory, Fundación Jiménez Díaz, Universidad Autónoma, Avda. Reyes Católicos, 2, 28040 Madrid, Spain. Tel.: (+34) 1 5504800x3168; fax: (+34) 1 5494764.
    • ,
  • Vanesa Esteban
    • ,
  • Jesús Egido

References 

  1. Albiston AL, McDowall SG, Matsacos D, et al. Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. J Biol Chem. 2001;276:48623–48626
  2. Ardaillou R. Active fragments of angiotensin II: enzymatic pathways of synthesis and biological effects. Curr Opin Nephrol Hypertens. 1997;6:28–34
  3. Chai SY, Fernando R, Peck G, et al. The angiotensin IV/AT4 receptor. Cell Mol Life Sci. 2004;61:2728–2737
  4. Chen JK, Zimpelmann J, Harris RC, Burns KD. Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells. Am J Physiol. 2001;280:F980–F988
  5. Chen S, Patel J, Block ER. Angiotensin IV–mediated pulmonary artery vasorelaxation is due to endothelial intracellular calcium release. Am J Physiol. 2000;279:L849–L856
  6. Daugherty A, Rateri DL, Lu H, et al. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation. 2004;21;110:3849–3857
  7. De Gasparo M, Catt KJ, Inagami T, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52:415–472
  8. Diet F, Pratt RE, Berry GJ, et al. Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease. Circulation. 1996;94:2756–2767
  9. Esteban V, Ruperez M, Sanchez-Lopez E, Rodriguez-Vita J, Lorenzo O, et al. Angiotensin IV activates the nuclear transcription factor-kappaB and related proinflammatory genes in vascular smooth muscle cells. Circ Res. 2005;96(9):965–973
  10. Ferreira AJ, Santos RA. Cardiovascular actions of angiotensin-(1–7). Braz J Med Biol Res. 2005;38:499–507
  11. Fukasawa K, Fujii H, Saitoh Y, et al. Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis. Cancer Lett. 2006;243:135–143
  12. Gesualdo L, Ranieri E, Monno R, et al. Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells. Kidney Int. 1999;56:461–470
  13. Hall KL, Hanesworth JM, Ball AE, et al. Identification and characterization of a novel angiotensin binding site in cultured vascular smooth muscle cells that is specific for the hexapeptide (3–8) fragment of angiotensin II, angiotensin IV. Regul Pept. 1993;44:225–232
  14. Hall KL, Venkateswaran S, Hanesworth JM, et al. Characterization of a functional angiotensin IV receptor on coronary microvascular endothelial cells. Regul Pept. 1995;58:107–115
  15. Handa RK, Krebs LT, Harding JW, et al. Angiotensin IV AT4-receptor system in the rat kidney. Am J Physiol. 1998;274:F290–F299
  16. Keller SR. Role of the insulin-regulated aminopeptidase IRAP in insulin action and diabetes. Biol Pharm Bull. 2004;27:761–764
  17. Kerins DM, Hao Q, Vaughn DE. Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J Clin Invest. 1995;96:2515–2520
  18. Kramar EA, Harding JW, Wrigh JW. Angiotensin II and IV–induced changes in cerebral blood flow: roles of AT1, AT2 and AT4 receptor subtypes. Regul Pept. 1997;68:131–138
  19. Krebs LT, Kramár EA, Hanesworth JM, et al. Characterization of the binding properties and physiological action of divalinal–angiotensin IV, a putative AT4 receptor antagonist. Regul Pept. 1996;67:123–130
  20. Lawnicka H, Potocka AM, Juzala A, et al. Angiotensin II and its fragments (angiotensins III and IV) decrease the growth of DU-145 prostate cancer in vitro. Med Sci Monit. 2004;10:BR410–BR413
  21. Lendeckel U, Arndt M, Wrenger S, et al. Expression and activity of ectopeptidases in fibrillating human atria. J Mol Cell Cardiol. 2001;33:1273–1281
  22. Lew RA, Mustafa T, McDowall SG, et al. Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP). J Neurochem. 2003;86:344–350
  23. Li YD, Block ER, Patel JM. Activation of multiple signaling modules is critical in angiotensin IV–induced lung endothelial cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2002;283:L707–L716
  24. Lu J, Zhang J, Block ER, Patel JM. Angiotensin IV enhances phosphorylation of 4EBP1 by multiple signaling events in lung endothelial cells. Mol Cell Biochem. 2005;275:181–188
  25. Meier P, Maillard M, Burnier M. The future of angiotensin II inhibition in cardiovascular medicine. Curr Drug Targets Cardiovasc Haematol Disord. 2005;5:15–30
  26. Moeller I, Clune EF, Fennessy PA, et al. Up-regulation of AT4 receptor levels in carotid arteries following balloon injury. Regul Pept. 1999;83:25–30
  27. Monaco C, Paleolog E. Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis. Cardiovasc Res. 2004;61:671–682
  28. Olivo Rdo A, Teixeira Cde F, Silveira PF. Representative aminopeptidases and prolyl endopeptidase from murine macrophages: comparative activity levels in resident and elicited cells. Biochem Pharmacol. 2005;69:1441–1450
  29. Olsen J, Kokholm K, Noren O, et al. Structure and expression of aminopeptidase. N Adv Exp Med Biol. 1997;421:47–57
  30. Petrescu G, Costuleanu M, Slatineanu SM, et al. Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity. J Renin Angiotensin Aldosterone Syst. 2001;2:180–187
  31. Pilar Carrera M, Ramirez-Exposito MJ, Duenas B, et al. Insulin-regulated aminopeptidase/placental leucil aminopeptidase (IRAP/P-lAP) and angiotensin IV–forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea. Anticancer Res. 2006;26:1011–1014
  32. Remuzzi G, Perico N, Macia M, et al. The role of renin–angiotensin–aldosterone system in the progression of chronic kidney disease. Kidney Int Suppl. 2005;99:S57–S65
  33. Ruiz-Ortega M, Esteban V, Ruperez M, et al. Renal and vascular hypertension-induced inflammation: role of angiotensin II. Curr Opin Nephrol Hypertens. 2006;15:159–166
  34. Ruiz-Ortega M, Lorenzo O, Egido J. Angiotensin III up-regulates genes involved in kidney damage in mesangial cells and renal interstitial fibroblasts. Kidney Int Suppl. 1998;68:S41–S45
  35. Ruiz-Ortega M, Lorenzo O, Egido J. Angiotensin III increases MCP-1 and activates NF-kappaB and AP-1 in cultured mesangial and mononuclear cells. Kidney Int. 2000;57:2285–2298
  36. Ruiz-Ortega M, Lorenzo O, Ruperez M, et al. Role of AT1 and AT2 receptors in angiotensin II–induced nuclear transcription factor κB activation in vascular smooth muscle cells. Circ Res. 2000;86:1266–1272
  37. Sano M, Itakura A, Ito M, et al. Placental leucine aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells. Med Sci Monit. 2005;11:BR195–BR199
  38. Santos RA, Simoes e Silva AC, Maric C, et al. Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A. 2003;100:8258–8263
  39. Sato Y. Role of aminopeptidase in angiogenesis. Biol Pharm Bull. 2004;27:772–776
  40. Schieffer B, Schieffer E, Hilfiker-Kleiner D, et al. Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability. Circulation. 2000;101:1372–1378
  41. Sihn G, Savary K, Michaud A, et al. Aminopeptidase N during the ontogeny of the chick. Differentiation. 2006;74:119–128
  42. Stragier B, Clinckers R, Meurs A, et al. Involvement of the somatostatin-2 receptor in the anti-convulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats. J Neurochem. 2006;98:1100–1113
  43. Thomas WG, Mendelsohn FA. Angiotensin receptors: form and function and distribution. Int J Biochem Cell Biol. 2003;35:774–779
  44. Vauquelin G, Michotte Y, Smolders I, et al. Cellular targets for angiotensin II fragments: pharmacological and molecular evidence. J Renin Angiotensin Aldosterone Syst. 2002;3:195–204
  45. Wang L, Eberhard M, Erne P. Stimulation of DNA and RNA synthesis in cultured rabbit cardiac fibroblast by angiotensin IV. Clin Sci. 1995;88:557–562
  46. Wright JW, Krebs LT, Stobb JW, et al. The angiotensin IV system: functional implications. Front Neuroendocrinol. 1995;16:23–52

PII: S1050-1738(06)00172-1

doi: 10.1016/j.tcm.2006.10.003

Trends in Cardiovascular Medicine
Volume 17, Issue 1 , Pages 19-25 , January 2007

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