Trends in Cardiovascular Medicine
Volume 17, Issue 2 , Pages 43-48, February 2007

Proteomics and Metabolomics Combined in Cardiovascular Research

  • Manuel Mayr

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Dr. Manuel Mayr, Cardiovascular Division, King's College, University of London, Bessemer Road, London SE5 9PJ, UK. Tel.: (+44) 20 3299 3036; fax: (+44) 20 3299 3510.
    • ,
  • Basetti Madhu
    • ,
  • Qingbo Xu

Cardiovascular Division, King's College, London SE5 9NU, UK

Cancer Research UK Cambridge Research Institute, Robinson way, Cambridge CB2 0RE, UK

Proteomics and metabolomics offer a nonbiased suite of tools to address pathophysiologic mechanisms from various levels by integrating signal transduction, cellular metabolism, and phenotype analysis. To link alterations of cellular proteins to metabolism and function, we have recently combined proteomic and metabolomic techniques. Examples, including genetic manipulation, ischemic preconditioning, atherosclerosis, and stem cell differentiation, are discussed to illustrate how the combination of these updated technologies may advance our understanding of cardiovascular biology.

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PII: S1050-1738(06)00176-9

doi:10.1016/j.tcm.2006.11.004

Trends in Cardiovascular Medicine
Volume 17, Issue 2 , Pages 43-48, February 2007

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