Trends in Cardiovascular Medicine
Volume 17, Issue 2 , Pages 59-63 , February 2007

Differentiation of Arterial, Venous, and Lymphatic Endothelial Cells From Vascular Progenitors

  • Jun K. Yamashita

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Dr. Jun K. Yamashita, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. Tel.: (+81) 75-751-3853; fax: (+81) 75-751-4824.

References 

  1. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol. 1999;154:385–394
  2. Cao R, Bjorndahl MA, Religa P, et al. PDGF-BB induces intratumoral lymangiogenesis and promotes lymphatic metastasis. Cancer Cell. 2004;6:333–345
  3. Carlson TR, Yan Y, Wu X, et al. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A. 2005;102:9884–9889
  4. Claxton S, Fruttiger M. Oxygen modifies artery differentiation and network morphogenesis in the retinal vasculature. Dev Dyn. 2005;233:822–828
  5. Coultas L, Chawengsaksophak K, Rossant J. Endothelial cells and VEGF in vascular development. Nature. 2005;438:937–945
  6. Duarte A, Hirashima M, Benedito R, et al. Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 2004;18:2474–2478
  7. Fischer A, Schumacher N, Maier M, et al. The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004;18:901–911
  8. Gale NW, Thurston G, Hackett SF, et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1. Dev Cell. 2002;3:411–423
  9. Gerety SS, Wang HU, Chen ZF, Anderson DJ. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell. 1999;4:403–414
  10. Groger M, Loewe R, Holnthoner W, et al. IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells. J Immunol. 2004;173:7161–7169
  11. Hirashima M, Kataoka H, Nishikawa S, et al. Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis. Blood. 1999;95:1253–1263
  12. Jain RK, Padera TP. Lymphatics make the break. Science. 2003;299:209–210
  13. Kajiya K, Hirakawa S, Ma B, et al. Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J. 2005;24:2885–2895
  14. Karkkainen MJ, Haiko P, Sainio K, et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol. 2004;5:74–80
  15. Kono T, Kubo H, Shimazu C, et al. Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells. Arterioscler Thromb Vasc Biol. 2006;26:2070–2076
  16. Krebs LT, Shutter JR, Tanigaki K, et al. Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 2004;18:2469–2473
  17. Kreuger J, Nilsson I, Kerjaschki D, et al. Early lymph vessel development from embryonic stem cells. Arterioscler Thromb Vasc Biol. 2006;26:1073–1078
  18. Lawson ND, Weinstein BM. Arteries and veins: making a difference with zebrafish. Nat Rev Genet. 2002;3:674–682
  19. Liersch R, Nay F, Lu L, Detmar M. Induction of lymphatic endothelial cell differentiation in embryoid bodies. Blood. 2006;107:1214–1216
  20. Loughna S, Sato TN. A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis. Mol Cell. 2001;7:233–239
  21. Lu X, Le Noble F, Yuan L, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004;432:179–186
  22. Makinen T, Veikkola T, Mustjoki S, et al. Isolated lymphatic endothelial cells transducer growth, survival, and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J. 2001;20:4762–4773
  23. Morisada T, Oike Y, Yamada Y, et al. Angiopoietin-1 promotes LYVE-1-positive lymphatic vessels formation. Blood. 2005;105:4649–4656
  24. Mukouyama YS, Shin D, Britsch S, et al. Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell. 2002;109:693–705
  25. Oliver G, Harvey N. A stepwise model of the development of lymphatic vasculature. Ann N Y Acad Sci. 2002;979:159–165
  26. Rajantie I, Ekman N, Iljin K, et al. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Mol Cell Biol. 2001;21:4647–4655
  27. Seki T, Yun J, Oh SP. Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res. 2003;93:682–689
  28. Shin D, Anderson DJ. Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells. Dev Dyn. 2005;233:1589–1604
  29. Tammela T, Saaristo A, Lohela M, et al. Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood. 2005;105:4642–4648
  30. Thurston G, Yancopoulos GD. Gridlock in the blood. Nature. 2001;414:163–164
  31. Villa N, Walker L, Lindsell CE, et al. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev. 2001;108:161–164
  32. Wang HU, Chen ZF, Anderson DJ. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrinB2 and its receptor Eph-B4. Cell. 1998;93:741–753
  33. Wigle JT, Harvey N, Detmar M, et al. An essential role for Prox1 in the induction of the lymphatic endothelial phenotype. EMBO J. 2002;21:1505–1513
  34. Yamashita J, Itoh H, Hirashima M, et al. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature. 2000;408:92–96
  35. Yoshioka M, Yuasa S, Matsumura K, et al. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. Nat Med. 2006;12:1151–1159
  36. You LR, Lin FJ, Lee CT, et al. Suppression of Notch signaling by the COUP-TFII transcription factor regulates vein identity. Nature. 2005;435:98–104
  37. Yuan L, Moyon D, Pardanaud L, et al. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development. 2002;129:4797–4806
  38. Yurugi-Kobayashi T, Itoh H, Yamashita J, et al. Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage. Blood. 2003;101:2675–2678
  39. Yurugi-Kobayashi T, Itoh H, Schroeder T, et al. Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol. 2006;26:1977–1984
  40. Zhong TP, Childs S, Leu JP, Fishman MC. Gridlock signaling pathway fashions the first embryonic artery. Nature. 2001;414:216–220

PII: S1050-1738(07)00003-5

doi: 10.1016/j.tcm.2007.01.001

Trends in Cardiovascular Medicine
Volume 17, Issue 2 , Pages 59-63 , February 2007