Trends in Cardiovascular Medicine
Volume 17, Issue 3 , Pages 83-90 , April 2007

Control of Cardiogenesis by the Notch Pathway

  • Thierry Pedrazzini

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Dr. Thierry Pedrazzini, Department of Medicine, University of Lausanne Medical School, CHUV MP14-220, CH-1011 Lausanne, Switzerland. Tel.: (+41) 21-314-0765; fax: (+41) 21-314-5978.

References 

  1. Androutsellis-Theotokis A, Leker RR, Soldner F, et al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature. 2006;442:823–826
  2. Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006;7:678–689
  3. Chau MD, Tuft R, Fogarty K, et al. Notch signaling plays a key role in cardiac cell differentiation. Mech Dev. 2006;123:626–640
  4. Conboy IM, Rando TA. The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Dev Cell. 2002;3:397–409
  5. Conboy IM, Conboy MJ, Smythe GM, et al. Notch-mediated restoration of regenerative potential to aged muscle. Science. 2003;302:1575–1577
  6. Conboy IM, Conboy MJ, Wagers AJ, et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433:760–764
  7. Conlon RA, Reaume AG, Rossant J. Notch1 is required for the coordinate segmentation of somites. Development. 1995;121:1533–1545
  8. Crosnier C, Stamataki D, Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet. 2006;7:349–359
  9. Crosnier C, Vargesson N, Gschmeissner S, et al. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development. 2005;132:1093–1104
  10. Dahlqvist C, Blokzijl A, Chapman G, et al. Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development. 2003;130:6089–6099
  11. Donovan J, Kordylewska A, Jan YN, et al. Tetralogy of Fallot and other congenital heart defects in Hey2 mutant mice. Curr Biol. 2002;12:1605–1610
  12. Fischer A, Klattig J, Kneitz B, et al. Hey basic helix–loop–helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol. 2005;25:8960–8970
  13. Fortini ME. Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol. 2002;3:673–684
  14. Fukuda K, Yuasa S. Stem cells as a source of regenerative cardiomyocytes. Circ Res. 2006;98:1002–1013
  15. Garg V, Muth AN, Ransom JF, et al. Mutations in NOTCH1 cause aortic valve disease. Nature. 2005;437:270–274
  16. Grego-Bessa J, Diez J, Timmerman L, et al. Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw. Cell Cycle. 2004;3:718–721
  17. Guo M, Jan LY, Jan YN. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neur. 1996;17:27–41
  18. Han Z, Bodmer R. Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development. 2003;130:3039–3051
  19. Iso T, Hamamori Y, Kedes L. Notch signaling in vascular development. Arterioscler Thromb Vasc Biol. 2003;23:543–553
  20. Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol. 2003;194:237–255
  21. Kadesch T. Notch signaling: the demise of elegant simplicity. Curr Opin Genet Dev. 2004;14:506–512
  22. Kathiriya IS, King IN, Murakami M, et al. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem. 2004;279:54937–54943
  23. Kidd S, Kelley MR, Young MW. Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Mol Cell Biol. 1986;6:3094–3108
  24. Kluppel M, Wrana JL. Turning it up a Notch: cross-talk between TGF beta and Notch signaling. BioEssays. 2005;27:115–118
  25. Kokubo H, Miyagawa-Tomita S, Tomimatsu H, et al. Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res. 2004;95:540–547
  26. Koo BK, Lim HS, Song R, et al. Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development. 2005;132:3459–3470
  27. Kwon C, Han Z, Olson EN, et al. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A. 2005;102:18986–18991
  28. Lai EC. Notch signaling: control of cell communication and cell fate. Development. 2004;131:965–973
  29. Lien CL, Schebesta M, Makino S, et al. Gene expression analysis of zebrafish heart regeneration. PLoS Biol. 2006;4:e260
  30. Loomes KM, Taichman DB, Glover CL, et al. Characterization of Notch receptor expression in the developing mammalian heart and liver. Am J Med Genet. 2002;112:181–189
  31. Lowell S, Jones P, Le Roux I, et al. Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol. 2000;10:491–500
  32. Lowell S, Benchoua A, Heavey B, et al. Notch promotes neural lineage entry by pluripotent embryonic stem cells. PLoS Biol. 2006;4:e121
  33. Luo D, Renault VM, Rando TA. The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis. Semin Cell Dev Biol. 2005;16:612–622
  34. McCright B, Gao X, Shen L, et al. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development. 2001;128:491–502
  35. McCright B, Lozier J, Gridley T. A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development. 2002;129:1075–1082
  36. McGill MA, McGlade CJ. Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem. 2003;278:23196–23203
  37. Milan DJ, Giokas AC, Serluca FC, et al. Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development. 2006;133:1125–1132
  38. Morrison SJ, Perez SE, Qiao Z, et al. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell. 2000;101:499–510
  39. Nemir M, Croquelois A, Pedrazzini T, et al. Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res. 2006;98:1471–1478
  40. Oka C, Nakano T, Wakeham A, et al. Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development. 1995;121:3291–3301
  41. Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor?. Nat Rev Cancer. 2003;3:756–767
  42. Radtke F, Wilson A, Mancini SJ, et al. Notch regulation of lymphocyte development and function. Nat Immun. 2004;5:247–253
  43. Raya A, Koth CM, Buscher D, et al. Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proc Natl Acad Sci U S A. 2003;100(Suppl 1):11889–11895
  44. Rones MS, McLaughlin KA, Raffin M, et al. Serrate and Notch specify cell fates in the heart field by suppressing cardiomyogenesis. Development. 2000;127:3865–3876
  45. Sainson RC, Harris AL. Hypoxia-regulated differentiation: let's step it up a Notch. Trends Mol Med. 2006;12:141–143
  46. Sakata Y, Kamei CN, Nakagami H, et al. Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A. 2002;99:16197–16202
  47. Schroeder T, Just U. Notch signalling via RBP-J promotes myeloid differentiation. EMBO J. 2000;19:2558–2568
  48. Schroeder T, Fraser ST, Ogawa M, et al. Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis. Proc Natl Acad Sci U S A. 2003;100:4018–4023
  49. Schroeder T, Meier-Stiegen F, Schwanbeck R, et al. Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development. Mech Dev. 2006;123:570–579
  50. Srivastava D. Making or breaking the heart: from lineage determination to morphogenesis. Cell. 2006;126:1037–1048
  51. Sundaram MV. The love-hate relationship between Ras and Notch. Genes Dev. 2005;19:1825–1839
  52. Swiatek PJ, Lindsell CE, del Amo FF, et al. Notch1 is essential for postimplantation development in mice. Genes Dev. 1994;8:707–719
  53. Timmerman LA, Grego-Bessa J, Raya A. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 2004;18:99–115
  54. Urbanek K, Cesselli D, Rota M, et al. Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A. 2006;103:9226–9231
  55. Watanabe Y, Kokubo H, Miyagawa-Tomita S, et al. Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development. 2006;133:1625–1634
  56. Wharton KA, Johansen KM, Xu T, et al. Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell. 1985;43:567–581
  57. Wilson A, Radtke F. Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett. 2006;580:2860–2868
  58. Xue Y, Gao X, Lindsell CE, et al. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet. 1999;8:723–730
  59. Ying QL, Nichols J, Chambers I, et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell. 2003;115:281–292

PII: S1050-1738(07)00031-X

doi: 10.1016/j.tcm.2007.01.003

Trends in Cardiovascular Medicine
Volume 17, Issue 3 , Pages 83-90 , April 2007