Trends in Cardiovascular Medicine
Volume 18, Issue 1 , Pages 20-25, January 2008

Vascular Cytochrome P450 Enzymes: Physiology and Pathophysiology

  • Ingrid Fleming

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Dr. Ingrid Fleming PhD, Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. Tel.: (+49) 69 6301 6972; fax: (+49) 69 6301 7668

Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, D-60590 Frankfurt am Main, Germany

Received 12 October 2007; received in revised form 2 November 2007; accepted 5 November 2007.

Cytochrome P450 epoxygenases and the soluble epoxide hydrolase are enzymes that regulate the cellular content of bioactive epoxides such as the epoxyeicosatrienoic acids derived from arachidonic acid. Epoxyeicosatrienoic acids are recognized as lipid mediators that participate in vascular signaling processes such as the acute regulation of vascular tone and the processes of inflammation and angiogenesis.

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PII: S1050-1738(07)00243-5

doi:10.1016/j.tcm.2007.11.002

Trends in Cardiovascular Medicine
Volume 18, Issue 1 , Pages 20-25, January 2008

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