Trends in Cardiovascular Medicine
Volume 18, Issue 1 , Pages 33-37, January 2008

Endothelial Progenitor Cells for Cardiovascular Regeneration

  • Atsuhiko Kawamoto

      Affiliations

    • Vascular Regeneration Research Group, Institute of Biomedical Research and Innovation, Kobe, Japan
    • Laboratory for Stem Cell Translational Research, RIKEN Center for Developmental Biology, Kobe, Japan
    • ,
  • Douglas W. Losordo

      Affiliations

    • Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    • Division of Cardiology, Program in Cardiovascular Regenerative Medicine, Northwestern Memorial Hospital, Chicago, IL 60611, USA
    • Corresponding Author InformationAddress correspondence to: Douglas W. Losordo, MD, Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Tarry 12-703303 East Chicago Ave. Chicago, IL 60611, USA. Tel.: (+1) 312 503 2296 fax: (+1) 312 503 0137

Received 24 September 2007; received in revised form 13 November 2007; accepted 15 November 2007.

Endothelial progenitor cells (EPCs) are peripheral blood mononuclear cells that can differentiate into mature endothelial cells. Adult EPCs were first discovered in human peripheral blood in 1997. Since then, the potency of EPCs for cardiovascular regeneration has been demonstrated in several preclinical studies; and investigators are beginning to evaluate the therapeutic utility of EPCs in early-phase clinical trials. This review summarizes the progression of basic, preclinical, and clinical research into the potential use of EPC therapy for cardiovascular regeneration.

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PII: S1050-1738(07)00245-9

doi:10.1016/j.tcm.2007.11.004

Trends in Cardiovascular Medicine
Volume 18, Issue 1 , Pages 33-37, January 2008

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