Trends in Cardiovascular Medicine
Volume 18, Issue 8 , Pages 299-305, November 2008

Endothelium-Driven Myocardial Growth or Nitric Oxide at the Crossroads

  • Daniela Tirziu
    • ,
  • Michael Simons

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Michael Simons, MD, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, P.O. Box 20801780217, New Haven, CT 06520, USA. Tel.: (+1) 203 785 7000

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA

Endothelium lining the coronary vasculature and the heart chambers is a dynamic sensor that serves a variety of functions including bidirectional communications with cardiac myocytes. Among endothelium-released factors, nitric oxide exerts multifactorial effects on various cell types in the heart and may play a role in growth of the vasculature and myocardial hypertrophy. This review summarizes new data regarding the endothelium-to-myocyte signaling focusing on its role in regulation of cardiac hypertrophy through a nitric-oxide-mediated paracrine signal.

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PII: S1050-1738(09)00017-6

doi:10.1016/j.tcm.2009.01.002

Trends in Cardiovascular Medicine
Volume 18, Issue 8 , Pages 299-305, November 2008

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