Trends in Cardiovascular Medicine
Volume 19, Issue 1 , Pages 6-11, January 2009

Assessment of Endothelial Function Using Digital Pulse Amplitude Tonometry☆☆☆

  • Naomi M. Hamburg

      Affiliations

    • Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA 02118
    • Corresponding Author InformationAddress correspondence to: Dr. Naomi M. Hamburg, Boston University, 88 East Newton Street C818, Boston, MA 02118, USA. Tel.: (+1) 617-638-7260; fax: (+1) 617-638-8756
    • ,
  • Emelia J. Benjamin

      Affiliations

    • Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA 02118
    • Whitaker Cardiovascular Institute, Preventive Medicine Section, Department of Medicine, Boston, MA 02118
    • Epidemiology Department, Boston University School of Public Health, Boston, MA 02118
    • The National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA 01702

The importance of endothelial dysfunction in the development and clinical expression of cardiovascular disease is well recognized. Impaired endothelial function has been associated with an increased risk of cardiovascular events. Endothelial function may be evaluated in humans by assessing vasodilation in response to stimuli known to induce the release of nitric oxide. A novel pulse amplitude tonometry device noninvasively measures vasodilator function in the microcirculation of the finger. This article reviews the recent studies that support the utility of digital pulse amplitude tonometry as a relevant test of peripheral endothelial function.

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☆ Dr Hamburg is supported by National Institutes of Health grant HL083781. Dr Benjamin receives support from RO1 HL076784, 1R01 AG028321, RO1 HL70100, and N01-HC 25195.

☆☆ Dr Benjamin has received an unrestricted research grant from Itamar Medical (Caesarea, Israel), the manufacturer of the PAT device.

PII: S1050-1738(09)00051-6

doi:10.1016/j.tcm.2009.03.001

Trends in Cardiovascular Medicine
Volume 19, Issue 1 , Pages 6-11, January 2009

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