Using New Tools to Define the Genetic Underpinnings of Risky Traits Associated With Coronary Artery Disease: The SardiNIA Study

Strait, James B.; Uda, Manuela; Lakatta, Edward G.; Najjar, Samer S.

doi:10.1016/j.tcm.2009.05.001

« Previous Next »Trends in Cardiovascular Medicine
Volume 19, Issue 3 , Pages 69-75, April 2009

Using New Tools to Define the Genetic Underpinnings of Risky Traits Associated With Coronary Artery Disease: The SardiNIA Study

James B. Strait
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
- Laboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Manuela Uda
- Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monseratto, Monserrato, Cagliari 09042, Italy.
Edward G. Lakatta
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Samer S. Najjar
- Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
- Address correspondence to: Dr. Samer S. Najjar, NIA/ASTRA Unit, 5th floor, Harbor Hospital, 3001 South Hanover Street Baltimore, MD 21225, USA

Abstract

Genomewide association studies are increasingly being applied to search for novel genes that might underlie cardiovascular diseases. In this article, we briefly review the principles that underlie modern genetic analyses and provide several illustrations from the SardiNIA study of genomewide association studies for cardiovascular risk factor traits.