Trends in Cardiovascular Medicine
Volume 19, Issue 4 , Pages 135-140, May 2009

Blood Relatives: Dynamic Regulation of Bioactive Lysophosphatidic Acid and Sphingosine-1-Phosphate Metabolism in the Circulation☆

The Gill Heart Institute, University of Kentucky College of Medicine, Lexington, KY 40536, USA

Veterans Affairs Medical Center, Lexington, KY 40502, USA

Lysophosphatidic acid and sphingosine 1-phosphate are bioactive lipid mediators with potent effects on cardiovascular development and vascular function. New studies define dynamic mechanisms that maintain physiologically relevant levels of both lipids in the blood. We review the mechanisms controlling the production, metabolism, and distribution of these lipids between vascular cells, circulating blood components, and the plasma.

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☆ The authors' work is supported by NIH grants HL078663 and HL074219, HL080166, GM050388, P20RR021954, T32HL091812, and a VA Merit Award. A. Salous is the recipient of an American Heart Association Pre-Doctoral Fellowship.

PII: S1050-1738(09)00108-X

doi:10.1016/j.tcm.2009.07.005

Trends in Cardiovascular Medicine
Volume 19, Issue 4 , Pages 135-140, May 2009

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