CredibleMeds.org: What does it offer?
Introduction
The CredibleMeds.org website is a unique resource for anyone seeking reliable information regarding the many drugs known to prolong the QT interval and cause the potentially lethal arrhythmia, torsades de pointes (TdP) [1]. In the 16 years since its launch, the website has grown from a simple list of drugs that cause TdP to a valuable clinical and research resource for patients, healthcare providers, and research scientists. The website was created by AZCERT, one of a network of 14 federally funded Centers for Education and Research on Therapeutics (CERTs) created to improve health outcomes from therapeutics [2], [3]. Initially based at the University of Arizona, AZCERT has focused on identifying drugs and drug-drug interactions that are responsible for QT prolongation and TdP. In 2012, AZCERT transitioned from a university-based program to a free-standing non-profit 501(c)3 corporation, now funded by the US Food and Drug Administration, research grants, and charitable contributions. AZCERT and its CredibleMeds website are recognized as the singular international resource for reliable, up to date, and independent information on medications, especially those associated with QT prolongation and/or TdP [1]. To prevent real or perceived bias in assessing QT or TdP causality for drugs, AZCERT does not accept funding from companies that have a commercial interest in medications.
Section snippets
What CredibleMeds.org offers
AZCERT curates and posts on the CredibleMeds website list of drugs based on their risk of TdP. The “QTdrugs” list includes all drugs that can affect the QT interval in humans and therefore have some risk of TdP. This list includes three subcategories of drugs, that is, those with Known Risk of TdP, those with Possible Risk of TdP, and those with Conditional Risk of TdP. The website also posts another list, drugs to avoid in patients with congenital long QT syndrome (CLQTS), which includes all
For Everyone: QTdrugs lists (registration required)
Under a contract with the U.S. Food and Drug Administration's Safe Use Initiative, AZCERT curates and posts on the CredibleMeds website lists of drugs that are associated with TdP and/or QT prolongation, commonly referred to as the QTdrugs lists [4]. The continually updated lists are currently accessed by over 96,000 registered visitors from 193 countries. Fifty six percentage of the registrants are healthcare providers, 39% are other individuals, and 5% are research scientists. A survey of
AZCERT's scientific review of drugs
Medications are evaluated for their association with drug-induced QT prolongation or TdP by a Scientific Review Committee with three physician members (R.L.W., C.W.H., and K.R.). The committee's decisions and recommendations for placement of drugs into TdP risk categories are reviewed by an International Advisory Board of 39 recognized authorities on drug safety and cardiovascular medicine (https://www.crediblemeds.org/research-scientists/advisory-board/).
AZCERT developed the process for
For Everyone: Create “My Medicines” online lists
To address one of the most challenging aspects of therapeutics, AZCERT has created an online repository for patients to create and maintain a list of the medicines they are taking. The user is prompted to remember to include hormones, vitamins, non-prescription medicines and dietary supplements. When creating the medicines list, the program informs the user if any drug they enter is in one of the four TdP risk categories and it will subsequently inform the user by e-mail if one of the drugs
Role of CredibleMeds in clinical decision support systems
The overall goal of the CredibleMeds website is to foster and support efforts to prevent TdP. Consensus papers have defined what actions are required for prevention of TdP but successful implementation requires that physicians be able to manage massive amounts of information about the drugs and about their patients [19]. This has prompted scientists to develop Clinical Decision Support Systems (CDSS) to help physicians and other members of the health care team to reach optimal medical and
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Cited by (72)
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction
2023, Journal of Pharmacological and Toxicological MethodsQT prolongation, torsades des pointes, and cardiac arrest after 4 mg of IV ondansetron
2023, American Journal of Emergency MedicinePrediction of drug pro-arrhythmic cardiotoxicity using a semi-physiologically based pharmacokinetic model linked to cardiac ionic currents inhibition
2022, Toxicology and Applied PharmacologyDrug-induced QT Prolongation Atlas (DIQTA) for enhancing cardiotoxicity management
2022, Drug Discovery TodayCitation Excerpt :To further improve the prediction of the occurrence of QT interval prolongation and TdP, a variety of data sources have been generated and applied. The CredibleMeds.org website provides a drug list in which the drugs are categorized into three subcategories based on their risk of TdP.10 The FDA maintains an electrocardiogram (ECG) warehouse for clinical data.
Drug-induced torsades de pointes
2022, Torsades de PointesMechanisms of torsades de pointes
2022, Torsades de Pointes
The authors have indicated there are no conflicts of interest.